>
产品中心 >
Functional_antibody >
PhosphoSolutions/Calcitonin Gene Related Peptide (CGRP) Antibody/311-CGRP/100 µl
Mousemonoclonalantibody
- Size:
- 100µl
- Formulation:
- ProteinGPurified
- Specificity:
- Rat,Human,Mostmammals
- Applications:
- ICC1:50-1:100
- Species:
- Mouse
- GeneName:
- CALCA
- CiteThisAntibody:
- PhosphoSolutionsCat#311-CGRP,RRID:AB_2492054
Antigen/Purification:Collapse
Theantigenisaratalpha-CGRP.
TheantibodyisproteinGpurified.
BIOLOGicalSignificance:Collapse
CalcitoninGeneRelatedPeptide[CGRP]isa37aminoacidpeptideandisthemostpotentendogenousvasodilatorcurrentlyknown(Brainetal.,1985).CGRPisprimarilyproducedinnervoustissue,however,itsreceptorsareexpressedthroughoutthebody.CGRPisalsostronglyimplicatedinthevasodilatoryeffectofendogenouscannABInoidanandamideinthebrain.Thiseffectwasfoundtobeantagonizedbycapsazepine.CGRPisalsocurrentlyamajortargetofresearchinregardstofactorseffectingtheonsetofmigraineheadaches(EdvinssonL.,2003).CGRPantibodieshavebeenusedsuccessfullyinimmunoneutralization(Wongetal.,1993)
Storage
100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternblots.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1yearafterdateofreceipt.Avoidfreeze/thawcycles.
GeneralReferences
BrainSD,WilliamsTJ,TippinsJR,MorrisHR,MacIntyreI(1985)Calcitoningenerelatedpeptideisapotentvasodilator.Nature313(5997):54-6
EdvinssonL(2003)Newtherapeutictargetinprimaryheadaches—blockingtheCGRPreceptor.ExpertOpinTherTargets.7(3):377-83
WongHC,Tache’Y,LloudKCK,YangH,SterniniC,HolzerP,WalshJH(1993)Monoclonalantibodytoratalpha-CGRP:production,characterization,andinvivoimmunoneutralizationactivity.Hybridoma.12:93-106.
