RabbitPolyclonalAntibody
- Size:
- 100µl
- Formulation:
- AffinityPurified
- Specificity:
- Rat,Mouse,Human
- Applications:
- WB1:2,000IF1:500
- Species:
- Rabbit
- MolecularReference:
- ~160kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#85-AC3,RRID:AB_2492029
Antigen/Purification:Collapse
TheantigenisasyntheticpeptidecorrespondingtoaminoacidresiduesfromtheC-terminalregionofratadenylatecyclaseIIIconjugatedtoKLH.
Theantibodyis affinitypurifiedrabbitserum.
BIOLOGicalSignificance:Collapse
Adenylatecyclaseistheenzymewhichproducesthe“secondmessenger”signalingmolecule,cAMPfromATP.TypeIIIadenylatecyclaseislocalizedtothemembranessurroundingneuronalcilia.Muchiscurrentlyunknownaboutthefunctionofprimaryciliainvertebrates,however,recentworkhasbeguntoexploretheirroleinneuronalsignalingandneurogenesis(FuchsandSchwark,2004;LouviandGrove2011).
Storage
100μlinPBS. Storeat–20°Cinundilutedaliquots;
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
GeneralReferences
FuchsJL,SchwarkHD.(2004)Neuronalprimarycilia:areview.CellBiolInt.28:111-8.
LouviAandGroveEA.(2011)CiliaintheCNS:thequietorganelleclaimscenterstage.Neuron69:1046-1060.
