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PhosphoSolutions/Collagen I, alpha 1, propeptide Antibody/321-COLP/100 µl
Rabbitpolyclonalantibody
- Size:
- 100µl
- Formulation:
- Affinitypurified
- Specificity:
- Rat,Mouse,Human
- Applications:
- WB1:1,000IHC1:100
- Species:
- Rabbit
- MolecularReference:
- ~180kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#321-COLP,RRID:AB_2492060
Antigen/Purification:Collapse
Theantigenisa peptidefromthehumancollagenIα1propeptidesequence.
Theantibodyisaffinitypurified.
BIOLOGicalSignificance:Collapse
Collagenisanextracellularmatrixproteinthatservesasascaffolddefiningtheshapeandmechanicalpropertiesofmanytissuesandorgansincludingskin,tendon,arterywalls,fibrocartilage,boneandteeth.Type1collagenisthemostabundantproteininmammals.CollagensaresynthesizedwithN-terminalandC-terminalpropeptidesthatarecleavedduringmaturationandsecretion.Aftercleavageofthepropeptides,themostN-terminalandC-terminalremainingsequencesareknownastelopeptides.Mutationsinthecollagen1,alpha1gene(COL1A1)areknowntocauseosteogenesisimperfecta(akabrittlebonedisease)(Byers1989).FurThermore,mutationsfoundinthefirst90residuesofthehelicalregionofalpha1collagenhavebeenimplicatedinthepreventionordelayedremovaloftheprocollagenN-propeptideleADIngtoacombinedosteogenesisimperfectaandEhlers-Danlossyndrome(EDS)phenotype(Cabraletal.,2005)
Storage
100µlinPBS.Adequateamountofmaterialtoconduct10-miniWesternBlots.
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.
ProductSpecificReferences
ReeseC,LeeR,BonnerM,PerryB,HeywoodJ,SilverRM,TourkinaE,ViscontiRP,HoffmanS.(2014)Fibrocytesinthefibroticlung:alteredphenotypedetectedbyflowcytometry.FrontPharmacol.2014Jun16;5:141.PMID:24999331
