Mousemonoclonalantibody
- Size:
- 100µl
- Formulation:
- ProteinGPurified
- Specificity:
- Rat,Mouse,Human,Bovine
- Applications:
- WB1:2,000IF1:500
- Species:
- Rabbit
- MolecularReference:
- ~21kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#1597-Park7,RRID:AB_2492201
Antigen/Purification:Collapse
Theantigenisafulllengthrecombinanthumanpark7expressedinandpurifiedfromE.coli.
TheantibodyisProteinGpurifiedfromtissueculturesupernatant.
BIOLOGicalSignificance:Collapse
Park7,alsoknownasDJ-1,isamemberofthepeptidaseC56familyofproteinsandisthoughttofunctionasamolecularchaperone.Mutationsinpark7havebeenassociatedwithautosomalrecessive,earlyonsetParkinson’sdisease(Bonifatietal.,2003).Recently,park7hasbeenshowntoinhibitmicrotubuleassociatedprotein1BaggregationthusleADIngtoneuronalapoptosis(Wangetal.,2011).
Storage
100ulinPBS+10mMsodiumazide.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
GeneralReferences
BonifatiV,RizzuP,vanBarenMJ,SchaapO,BreedveldGJ,KriegerE,DekkerMC,SquitieriF,IbanezP,JoosseM,vanDongenJW,VanacoreN,vanSwietenJC,BriceA,MecoG,vanDuijnCM,OostraBA,HeutinkP.(2003)MutationsintheDJ-1geneassociatedwithautosomalrecessiveearly-onsetparkinsonism.Science.Jan10;299(5604):256-9
WangZ,ZhangY,ZhangS,GuoQ,TanY,WangX,XiongR,DingJ,ChenS.(2011)DJ-1caninhibitmicrotubuleassociatedprotein1Bformedaggregates.MolNeurodegener.Jun6;6:38
