Rabbit polyclonal antibody
- Size:
- 100 µl
- Formulation:
- Protein A Purified
- Specificity:
- Human, Mouse, Rat
- Applications:
- WB 1:3,000IHC 1:100IP 1:50ICC 1:100
- Species:
- Rabbit
- Molecular Reference:
- ~27 kDa
- Cite This Antibody:
- PhosphoSolutions Cat# 1537-Olig1, RRID:AB_2492192
Antigen/Purification: Collapse
The antigen is a recombinant mouse Olig1.
The antibody is Protein A purified rabbit serum.
Biological Significance: Collapse
Olig genes have been identified as the earliest known markers of oligodendrocyte lineage determination to date (Zhou et al., 2000). Olig1 is a transcription factor which promotes formation and maturation of oligodendrocytes, especially within the brain. It is expressed in the ventral spinal cord as early as 9.5 dpc and by 15.5 dpc, olig1 is dispersed throughout the gray matter. In the postnatal brain, it is present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Olig1 has been demonstrated as necessary in the repair of brain lesions in patients with multiple sclerosis (Arnett et al. 2004).
Storage
Liquid in 100 mM Glycine, 200 mM Tris, pH 8.0. Contains no preservative.
For long term storage –20° C is recommended in undiluted aliquots. Stable at –20° C for at least one year after date of receipt. Avoid freeze/thaw cycles.
General References
Zhou Q, Wang S, Anderson DJ (2000) Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 25(2):331-43.
Arnett, H.A., et al. (2004) bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 306(5704):2111-5.
