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Functional_antibody >
PhosphoSolutions/Norepinephrine Transporter Antibody/1447-NET/100 µl
Mousemonoclonalantibody
- Size:
- 100µl
- Formulation:
- ProteinGPurified
- Specificity:
- Rat,Mouse
- Applications:
- WB1:2,000
- Species:
- Mouse
- MolecularReference:
- ~55kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#1447-NET,RRID:AB_2492187
Antigen/Purification:Collapse
Theantigenis asyntheticpeptidefromN-terminalregionofmousenorepinephrinetransporter.
TheantibodyisProteinGpurifiedculturesupernatant.
BIOLOGicalSignificance:Collapse
NorepinephrineTransporter[NET](ornoradrenalinetransporter(NAT))isamonoaminetransporterthattransportstheneurotransmitternoradrenalinefromthesynapsebacktoitsvesiclesforstorageuntillateruse.Italsoappearstotransporttheneurotransmitterdopamineinthesameway,buttoalesserdegree.StudieshaveshownadecreaseinNETlevelsinthelocuscoeruleusinpatientsdiagnosedwithmajordepression(Klimeketal.,1997).Cocaine,amphetaminesandmanytherapeuticantidepressants,suchastheSNRIs(SEROtonin-norepinephrinereuptakeinhibitors)andthetricyclicantidepressants(TCAs)acttoraisenoradrenaline.FurThermore,deficitsintheNETgenehavebeenassociatedwithADHD(Kimetal.,2006).
Storage
100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternblots.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforuptooneyearafterdateofreceipt.Avoidfreeze/thawcycles.
ProductSpecificReferences
Andreoli,M.,Marketkar,T.andDimitrov,E.,2017.ContributionofamygdalaCRFneuronstochronicpain.ExperimentalNeurology,298,pp.1-12.PMID:28830762
