Rabbitpolyclonalantibody
- Size:
- 50µl
- Formulation:
- Neatserum
- Specificity:
- Rat,Mouse,Human,Sheep,Rabbit
- Applications:
- WB1:1,000IHC1:1,000
- Species:
- Rabbit
- MolecularReference:
- ~46kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#327-CON,RRID:AB_2492063
Antigen/Purification:Collapse
Theantigenisan endogenousrabbit2,3-cyclicnucleotide-3-phospho-diesterase.
Theantibodyisneatserum.
BIOLOGicalSignificance:Collapse
2,3-cyclicnucleotide-3-phosphodiesterase(CNP)isamembranebound,microtubuleassociatedproteinthatisamongthemostabundantmyelinproteinsoftheCNS.ItisthoughtthatCNPmayserveasaregulatoroftubulinpolymerizationandofmicrotubuledistribution(Bifulcoetal.,2002).ItwasrecentlyfoundthatCNPmayalsofunctionasapossIBLelinkerproteinanchoringmicrotubulestotheplasmamembraneviaa13residueC-terminalCNPfragment(Bifulcoetal.,2002,Espositoetal.,2008).
Storage
50ulneatserum.
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.
GeneralReferences
Bifulcoetal.2,3-Cyclicnucleotide3-phosphodiesterase:amembranebound,microtubuleassociatedproteinandmembraneanchortubulin.PNAS99:1807-12,2002.
EspositoC,ScrimaM,CarotenutoA,TedeschiA,RoveroP,D’EbifulcoM,D’ErricoG,MalfitanoAM,D’UrsiAM(2008)StructuresandmicellelocationsofthenonlipidatedandlipidatedC-terminalanchorof2,3-Cyclicnucleotide3-phosphodiesterase.Biochemistry47(1):308-319.
