Mousemonoclonalantibody
- Size:
- 100µl
- Formulation:
- ProteinGPurified
- Specificity:
- Rat,Mouse,Human,Bovine
- Applications:
- WB1:5,000IF1:500
- Species:
- Mouse
- MolecularReference:
- ~46/48kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#581-FOX1,RRID:AB_2492095
Antigen/Purification:Collapse
TheantigenisarecombinantproteintakenfromtheN-terminusofhumanFOX1expressedinandpurifiedfromE.Coli.
TheantibodyisProteinGpurifiedfromculturesupernatant.
BIOLOGicalSignificance:Collapse
FOX1,alsoknownasataxin-2bindingprotein1(A2BP1),isaneuronspecificRNA-bindingproteinthathasbeenshowntoregulateawiderangeofalternativesplicingeventsimplicatedinneuronaldevelopmentandmaturationincludingtranscriptionfactorsandsynapticproteins(Fogeletal.,2012).DefectsinFOX1havealsobeenassociatedwithautism(Martinetal.,2007),attention-deficithyperactivitydisorder(Eliaetal.,2010)andschizophrenia(Xuetal.,2008).
Storage
100µlinPBS+10mMsodiumazide.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
GeneralReferences
EliaJ,GaiX,XieHM,PerinJC,GeigerE,GlessnerJT,D’arcyM,deBerardinisR,FrackeltonE,KimC,LantieriF,MugangaBM,WangL,TakedaT,RappaportEF,GrantSF,BerrettiniW,DevotoM,ShaikhTH,HakonarsonH,WhitePS.(2010)Rarestructuralvariantsfoundinattention-deficithyperactivitydisorderarepreferentiallyassociatedwithneurodevelopmentalgenes.MolPsychiatry.Jun;15(6):637-46.
FogelBL,WexlerE,WahnichA,FriedrichT,VijayendranC,GaoF,ParikshakN,KonopkaG,GeschwindDH.(2012)RBFOX1regulatesbothsplicingandtranscriptionalnetworksinhumanneuronaldevelopment.HumMolGenet.Oct1;21(19):4171-86.
MartinCL,DuvallJA,IlkinY,SimonJS,ArreazaMG,WilkesK,Alvarez-RetuertoA,WhichelloA,PowellCM,RaoK,CookE,GeschwindDH.(2007)CytogeneticandmolecularcharacterizationofA2BP1/FOX1asacandidategeneforautism.AmJMedGenetBNeuropsychiatrGenet.Oct5;144B(7):869-76.
XuB,RoosJL,LevyS,vanRensburgEJ,GogosJA,KarayiorgouM.(2008)StrongassociationofdenovocopynumbermutationswithsporADIcschizophrenia.NatGenet.Jul;40(7):880-5.
