Mousemonoclonalantibody
- Size:
- 100µl
- Formulation:
- ProteinGPurified
- Specificity:
- Human,Mouse,Rat
- Applications:
- WB1:1000IF1:500
- Species:
- Mouse
- MolecularReference:
- ~60kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#750-HSP60,RRID:AB_2715493
Antigen/Purification:Collapse
TheantigenisrecombinantfulllengthhumanHSP60protein.
TheantibodyisproteinGpurifiedfromculturesupernatant.
BIOLOGicalSignificance:Collapse
HSP60isamemberoftheheatshockproteinfamilywhichisthoughttoplayakeyroleinmitochondrialproteintransportandproperrefoldingofproteinsimportedfromthecytoplasmintothemitochondrialmatrix(Kolletal.,1992). Morerecently,HSP60hasbeenimplicatedinthepathogenesisofcardiovasculardisease(Rizzoetal.,2011).
Storage
100µlinPBS+50%glyceroland 5mMsodiumazide.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
GeneralReferences
KollH,GuiardB,RassowJ,OstermannJ,HorwichAL,NeupertW,HartlFU.(1992) AntifoldingactivityofHSP60couplesproteinimportintothemitochondrialmatrixwithexporttotheintermembranespace. Cell68:1163-75.
RizzoM, MacarioAJ, deMacarioEC, Gouni-BertholdI, BertholdHK, RiniGB, ZummoG, CappelloF.(2011)Heatshockprotein-60andriskforcardiovasculardisease.CurrPharmDes17:3662-8.
