Mousemonoclonalantibody
- Size:
- 100µl
- Formulation:
- ProteinGPurified
- Specificity:
- Rat,Mouse,Human,Bovine
- Applications:
- WB1:5,000IF1:1,000
- Species:
- Mouse
- MolecularReference:
- ~100kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#1030-LAMP1,RRID:AB_2492140
Antigen/Purification:Collapse
TheantigenisarecombinantfulllengthhumanLAMP1expressedinandpurifiedfromE.Coli.
TheantibodyisProteinGpurifiedfromtissueculturesupernatant.
BIOLOGicalSignificance:Collapse
LysosomalAssociatedMembraneProtein1(LAMP1)isaproteinthatislocalizedprimarilyinlysosomesbutmayalsobepresentonlateendosomesandtheplasmamembrane.LAMP1antibodiesarethereforewidelyusedaslysosomeMarkers.Ithasrecentlybeensuggestedthatlysosomesareactivatedinmicrogliaintheprogressionofmultiplesystematrophy(MSA)andthusplayakeyroleinitspathology(Makiokaetal.,2012).
Storage
100µlinPBS+10mMsodiumazide.
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.
GeneralReferences
MakiokaK,YamazakiT,TakatamaM,NakazatoY,OkamotoK.(2012)Activationandalterationoflysosomesinmultiplesystematrophy.Neuroreport.Mar28;23(5):270-6.
