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PhosphoSolutions/TFAM (Transcription Factor A, mitochondrial) Antibody, Human/1999-hTFAM/100 µl
Rabbitpolyclonalantibody
- Size:
- 100µl
- Formulation:
- Neatserum
- Specificity:
- Human
- Applications:
- WB1:2,000
- Species:
- Rabbit
- MolecularReference:
- ~24kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#1999-hTFAM,RRID:AB_2571641
Antigen/Purification:Collapse
Theantigenisa nativerecombinanthuman TFAMproteinwithc-terminal6-histag.
Theantibodyisserum.
BIOLOGicalSignificance:Collapse
MitochondrialTranscriptionFactorA(TFAM)isakeyactivatorofmitochondrial(mt)DNAtranscriptionaswellasaparticipantinmitochondrialgenomereplication.mtDNAishighlysusceptIBLetooxidativestressleADIngtomitochondrialdysfunction.OverexpressionofTFAMhasbeenimplicatedintheameliorationofagedependentimpairmentofbrainfunctionsthroughthepreventionofoxidativestressandmitochondrialdysfunctioninmicroglia(Hayashietal.,2008).Morerecently,TFAMoverexpressionhasbeenshowntopotentiallyreduceoxidativestressinmotorneuronsanddelayonsetofamyotrophiclateralsclerosis(ALS)inALSmodelmice(Morimotoetal.,2012).
Storage
100ulneatserum.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
GeneralReferences
HayashiY,YoshidaM,YamatoM,IdeT,WuZ,Ochi-ShindouM,KankiT,KangD,SunagawaK,TsutsuiH,NakanishiH(2008)Reverseofage-dependentmemoryimpairmentandmitochondrialDNAdamageinmicrogliabyanoverexpressionofhumanmitochondrialtranscriptionfactorainmice.JNeurosci.28(34):8624-34
MorimotoN,MiyazakiK,KurataT,IkedaY,MatsuuraT,KangD,IdeT,AbeK(2012)Effectofmitochondrialtranscriptionfactoraoverexpressiononmotorneuronsinamyotrophiclateralsclerosismodelmice.JNeurosciRes.90(6):1200-8.Epub2012Feb22
