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Functional_antibody >
PhosphoSolutions/GABAB R1 (Ser923) Antibody/p1148-923/100 µl
Rabbitpolyclonalantibody
PooledSerum- Size:
- 100µl
- Formulation:
- AffinityPurifiedfromPooledSerum
- Specificity:
- Rat,Mouse,Human,Bovine,Non-humanprimate
- Applications:
- WB1:1,000
- Species:
- Rabbit
- GeneName:
- GABBR1
- MolecularReference:
- ~102kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#p1148-923,RRID:AB_2492118
Antigen/Purification:Collapse
Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser923ofGABABR1.
Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.
BIOLOGicalSignificance:Collapse
Gamma-aminobutyricacid(GABA)istheprimaryinhibitoryneurotransmitterinthecentralnervoussystem.TherearetwomajorclassesofGABAreceptors:theGABAAandtheGABABsubtypeofreceptors.GABABreceptorsareheterodimericGprotein-coupledreceptorsthatmediateslowsynapticinhibitioninthecentralnervoussystem.PhosphorylationenhancesGABAB receptoreffectorcoupling(Couveetal.,2004).PhosphorylationofSer923isthoughttobeimportantintheregulationofGABABreceptorfunction.
Storage
100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.
GeneralReferences
CouveA,CalverAR,FairfaxB,MossSJ,PangalosMN(2004)UnravellingtheunusualsignalingproertiesoftheGABA(B)receptor.Biochem.Pharmacol.Oct12;68(8):1527-36.
