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当前位置: 首页 > 产品中心 > Functional_antibody > 磷酸溶液/NMDA受体NR2B亚单位N端抗体/1503-NR2B/100µl
商品详细磷酸溶液/NMDA受体NR2B亚单位N端抗体/1503-NR2B/100µl
磷酸溶液/NMDA受体NR2B亚单位N端抗体/1503-NR2B/100µl
磷酸溶液/NMDA受体NR2B亚单位N端抗体/1503-NR2B/100µl
商品编号: 1503-NR2B
品牌: PhosphoSolutions
市场价: ¥4574.70
美元价: 3519.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Rat,Mouse,Human,Bovine,Chicken,Non-humanprimate,Canine
Applications:
WB1:1,000IHC1:500
Species:
Rabbit
GeneName:
GRIN2B
MolecularReference:
~180kDa
CiteThisAntibody:
PhosphoSolutionsCat#1503-NR2B,RRID:AB_2492178
Antigen/Purification:ExpandCollapse

TheantigenisapeptidefromtheN-terminusoftheNR2BsubunitofratNMDAreceptor.

Theantibodyispreparedfromrabbitserumbyaffinitypurificationusingacolumntowhichthepeptideimmunogenwascoupled.

BIOLOGicalSignificance:ExpandCollapse

TheionchannelsactivatedbyglutamatethataresensitivetoN-methyl-D-aspartate(NMDA)aredesignatedNMDAreceptors(NMDAR).TheNMDARplaysanessentialroleinmemory,neuronaldevelopmentandithasalsobeenimplicatedinseveraldisordersofthecentralnervoussystemincludingAlzheimer’s,epilepsyandischemicneuronalcelldeath(Grosshansetal.,2002;Wentholdetal.,2003;CarrollandZukin,2002).TheNMDAreceptorisalsooneoftheprincipalmoleculartargetsforalcoholintheCNS(Lovingeretal.,1989;Alvestadetal.,2003;Snelletal.,1996).TheratNMDAR1(NR1)wasthefirstsubunitoftheNMDARtobeclonedanditcanformNMDAactivatedchannelswhenexpressedinXenopusoocytesbutthecurrentsinsuchchannelsaremuchsmallerthanthoseseeninsitu.ChannelswithmorephysiologicalcharacteristicsareproducedwhentheNR1subunitiscombinedwithoneormoreoftheNMDAR2(NR2A-D)subunits.OverexpressionoftheNR2B-subunitoftheNMDAreceptorhasbeenassociatedwithincreasesinlearningandmemorywhileaged,memoryimpairedanimalshavedeficienciesinNR2Bexpression(Claytonetal.,2002a;Claytonetal.,2002b).TheNMDARisalsopotentiatedbyproteinphosphorylation(Luetal.,1999).

Storage

100μlantibodyvialin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

AlvestadRM,GrosshansDR,CoultrapSJ,NakazawaT,YamamotoT,BrowningMD(2003)TyrosinedephosphorylationandethanolinhibitionofN-methyl-D-aspartatereceptorfunction.JBiolChem278:11020-11025.

CarrollRC,ZukinRS(2002)NMDA-receptortraffickingandtargeting:implicationsforsynaptictransmissionandplasticity.TrendsNeurosci25:571-577.

GrosshansDR,ClaytonDA,CoultrapSJ,BrowningMD(2002)LTPleadstorapidsurfaceexpressionofNMDAbutnotAMPAreceptorsinadultratCA1.NatNeurosci5:27-33.

LovingerDM,WhiteG,WeightFF(1989)EthanolinhibitsNMDA-activatedioncurrentinhippocampalneurons.Science243:1721-1724.

LuW-Y,XiongZ-G,LeiS,OrserBA,BrowningMD,MacDonaldJF(1999)G-proteincoupledreceptorsactviaproteinkinaseCandSrctoregulateNMDAreceptors.NatureNeurosci2:331-338.

SnellLD,NunleyKR,LickteigRL,BrowningMD,TabakoffB,HoffmanPL(1996)RegionalandsubunitspecificchangesinNMDAreceptormRNAandimmunoreactivityinmousebrainfollowingchronicethanolingestion.MolBrainRes40:71-78.

WentholdRJ,PrybylowskiK,StandleyS,SansN,PetraliaRS(2003)TraffickingofNMDAreceptors.AnnuRevPharmacolToxicol43:335-358.

Note:Dr.MichaelBrowning,aco-authoroffourofthecitedpapers,isCEOandfounderofPhosphoSolutions.

品牌介绍
 有效的抗体!是什么让PhosphoSolutions与众不同?如果我们试图制造一种抗体但它不起作用,我们就把它扔掉。PhosphoSolutions从不出售无法在我们手中发挥作用的抗体。PhosphoSolutions对严格验证标准的承诺可确保内源性蛋白质中的信号清晰,并验证相关产品的磷酸化特异性。PhosphoSolutions致力于重现性。寻找我们的“混合血清”图标。带有此图标的每种抗体均从其自身的血清库中纯化,以确保批次间的一致性。我们保证我们的抗体。如果您不能让抗体在您的申请中发挥作用,我们将提供100% 的退款。在制作定制抗体时,PhosphoSolutions从头到尾提供个性化的客户支持,从肽设计、纯化到表征。