Rabbitpolyclonalantibody
- Size:
- 100µl
- Formulation:
- ProteinAPurified
- Specificity:
- Rat,Mouse,Human
- Applications:
- WB1:3,000IHC1:1,000IP1:500-1:1,000
- Species:
- Rabbit
- MolecularReference:
- ~32kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#1538-Olig2,RRID:AB_2492193
Antigen/Purification:Collapse
TheantigenisarecombinantmouseOlig2.
TheantibodyisProteinApurifiedrabbitserum.
BIOLOGicalSignificance:Collapse
Olig2isatranscriptionfactorwhichisrequiredforoligodendrocyteandmotorneuronspecificationinthespinalcord,aswellasforthedevelopmentofsomaticmotorneuronsinthehindbrain.Expressedintheventralspinalcordasearlyas9.5dpcandscatteredinthemantlezone,likelycorrespondingtooligodendrocyteProgenitorsmigratingoutfromtheirsiteoforigin.From10.5through14.5dpc,Olig2isexpressedinnumerouscellsintheventricularandsubventricularzonesofthelateralandmedialganglioniceminences,suggestingthatexpressionmightnotbelimitedtotheoligodendrocyticlineage.Olig2hasfurtherbeenshowntobecriticalintheproliferationofmalignantgliomainbraintumors(Ligonetal.,2007)
Storage
Liquidin100mMGlycine,200mMTris,pH8.0.Containsnopreservative.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforforuptooneyearafterdateofreceipt.Avoidfreeze/thawcycles.
ProductSpecificReferences
Kucharova,K.,&Stallcup,W.B.(2015).NG2-proteoglycan-dependentcontributionsofoligodendrocyteprogenitorsandmyeloidcellstomyelindamageandrepair.Journalofneuroinflammation,12(1),161.PMID:26338007
Mauney,S.A.,Pietersen,C.Y.,Sonntag,K.C.,&Woo,T.U.W.(2015).Differentiationofoligodendrocyteprecursorsisimpairedintheprefrontalcortexinschizophrenia.SchizophreniaResearch,169(1),374-380.PMID:26585218
NorwoodJ,FranklinJM,SharmaD,D’MelloSR(2014)Histonedeacetylase3isnecessaryforproperbraindevelopment.JBiolChem.2014Dec12;289(50):34569-34582.PMID:25339172
