Rabbitpolyclonalantibody
- Size:
- 100µl
- Formulation:
- Neatserum
- Specificity:
- Rat
- Applications:
- WB1:1,000
- Species:
- Rabbit
- MolecularReference:
- ~22kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#1600-PEBP,RRID:AB_2492204
Antigen/Purification:Collapse
TheantigenisanativePEBPproteinpurifiedfromrat.
Theantibodyisneatserum.
BIOLOGicalSignificance:Collapse
Phosphatidylethanolaminebindingprotein(PEBP),alsoknownasRafkinaseinhibitoryprotein(RKIP)isahighlyconservedmultifunctionalproteinthatmodulatestheRaf/MAPKsignalingcascadeandhasbeenimplicatedasasuppressorofmetastaticcancer(TrakulNetal.,2005).PEBPhasbeenshowntonotonlyinhibitcellproliferationbutalsotoinducedifferentiationofhumankeratinocytes(Yamazakietal.,2004).DysregulationofcalpainactivityresultsincellulardegenerationinconditionssuchasAlzheimer’sdiseaseandrecentlyPEBPhasbeenidentifiedasapotentialinvivocalpainsubstrate(Chenatal.,2006).
Storage
100ulneatserum.
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.
GeneralReferences
TrakulN,MenardRE,SchadeGR,QianZ,RosnerMR(2005)RafkinaseinhibitoryproteinregulatesRaf-1butnotB-Rafkinaseactivation.J.Biol.Chem.280(26):24931-40.
YamazakiT,NakanoH,HayakariM,TanakaM,MayamaJ,TsuchidaS(2004)Differentiationinductionofhumankeratinocytesbyphosphatidylethanolaminebindingprotein.J.Biol.Chem.279(31):32191-95.
ChenQ,WangS,ThompsonSN,HallED,GuttmannRP(2006)IdentificationandcharacterizationofPEBPasacalpainsubstrate.JNeuRochem.99(4):1133-41.
