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Functional_antibody >
PhosphoSolutions/Cyclin-dependent kinase 5 (Cdk5) Antibody/308-CDK5/100 µl
Mousemonoclonalantibody
- Size:
- 100µl
- Formulation:
- ProteinGPurified
- Specificity:
- Rat,Mouse,Human
- Applications:
- WB1:1,000IHC1:500
- Species:
- Rat
- MolecularReference:
- ~28kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#308-CDK5,RRID:AB_2492053
Antigen/Purification:Collapse
TheantigenisapurifiedratCdk5.
TheantibodyisproteinGpurifiedculturesupernatant.
BIOLOGicalSignificance:Collapse
Theneuronalproteinkinase,Cdk5hasbeenimplicatedinavastarrayofnormalneuronalfunctionsincludingregulationofneurotransmittersynthesis(KansyJetal.,2004),thepresynapticvesiclecycle(Nguyen,C.&Bibb,JA2003),neurotransmitterreceptortraffickinganddopamineneurotransmission(Bibb,JAetal.1999).AtthesametimeCdk5hasbeenimplicatedinaplethoraofneurologicalandneuropsychiatricdisordersincludingAlzheimer’s,Parkinson’s,Huntington’s,epilepsy,schizophrenia,anddrugaddiction.DetectionofCdk5innormalsamplesaswellastissueundergoingneurodegenerationmayadvancestudiesintheseareas.Moreover,thisantibodymayallowmoreaccuratepostmortemevaluationsofCdk5proteinexpression,andthusserveasavaluablenewreagentforneuropathology.
Storage
100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.
ProductSpecificReferences
Hernandez,A.,Tan,C.,Mettlach,G.,Pozo,K.,Plattner,F.,&Bibb,J.A.(2016).Cdk5ModulatesLong-TermSynapticPlasticityandMotorLearninginDorsolateralStriatum.ScientificReports,6.PMID:27443506
Lagace,D.C.etal.Cdk5isessentialforadulthippocampalneurogenesis.ProcNatlAcadSciUSA105,18567–18571(2008). PMID:19017796
