Chickenpolyclonalantibody
- Size:
- 100µl
- Formulation:
- TotalIgYfraction
- Specificity:
- Rat,Human
- Applications:
- WB1:10,000IF1:1,000
- Species:
- Chicken
- MolecularReference:
- ~48kDa,~65kDa&~75kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#1998-TAU,RRID:AB_2492256
Antigen/Purification:Collapse
TheantigenisarecombinantfulllengthhumantauexpressedinandpurifiedfromE.Coli.
TheantibodyistotalIgYfraction.
BIOLOGicalSignificance:Collapse
Tauisakeymicrotubule-associatedproteinthatplaysanimportantroleintheformationofmicrotubulesinaxons(Binderetal.1985).SixtauisoformshavebeenidentifiedasproductsofasinglegeneproducedbyalternativemRNAsplicing(Goedert1990).TaumutationshavebeenimplicatedinmanyneurodegenerativedisorderssuchasAlzheimer’sdisease(AD),Pick’sdiseaseandprogressivesupranuclearpalsy.
Storage
100ulliquidcontaining10mMsodiumazide.
Forlongtermstorage–20°Cisrecommendedinundilutedaliquots.Stableat–20°Cforatleast1year.Avoidfreeze/thawcycles.
GeneralReferences
BinderLI,FrankfurterA,RebhunLI(1985)Thedistributionoftauinthemammaliancentralnervoussystem.JCellBioOct;101(4):1371-8.
GoedertM.andJakesR.(1990)Expressionofseparateisoformsofhumantauprotein:correlationwiththetaupatterninbrainandeffectsontubulinpolymerization.EMBOJ9,4225-4230
